Mandible / maxilla – Malignant tumors: ameloblastic fibrosarcoma. A case of an ameloblastic fibrosarcoma in the mandible is described. The primary tumor was seen in a 5-year-old child. In spite of repeated surgical. Introduction. Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor. It can arise de novo, however one-third of cases may arise from a recurrent.

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Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up

Sign up for our Email Newsletters. Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. This article has been cited by other articles in PMC. Surgical resection with a wide margin is the optimal treatment strategy Adjuvant chemotherapy and radiotherapy as needed; may reduce the recurrence rate and enhance the quality of life. National Center for Biotechnology InformationU. Published online Mar Abstract Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma.

CD34 expressing ameloblastic fibrosarcoma arising in the maxilla: We report the case of a year-old female with a 2-month history of an asymptomatic swelling in her left mandible. In summary, AFS is a rare malignant odontogenic tumor characterized by a benign odontogenic epithelium and a malignant mesenchymal component that can arise from a previous AF or de novo. Postoperative chemotherapy and radiotherapy has been used successfully in a few reported cases.

They are derived from epithelial, ectomesenchymal, and mesenchymal elements of the tooth-forming apparatus. Click here for patient related inquiries. The final histopathological diagnosis was identical to that of the incisional biopsy and an AFS was confirmed. Ameloblstic majority of reported cases have been found in the posterior region of mandible and rarely maxillary involvement is indicated.


Because of rarity of cases, it is almost impossible to estimate long-term prognosis accurately and many patients have died from uncontrolled local invasive disease.

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Clinically, patients present with pain and swelling [ 3 qmeloblastic and the mandible is the most commonly affected site [ 1 ]. Accessed December 31st, In view of these histopathological and immunohistochemistry findings, an AFS was diagnosed.

Footnotes Source of Support: Approximately, one ameloblstic of reported cases appear to originate from recurrence of a previous ameloblastic fibroma. Radiographically, the tumor usually shows a destructive radiolucent pattern with ill-defined borders suggestive of malignancy. Case Report A year-old female presented with a 2-month history of an asymptomatic swelling in her left mandible.

Those lesions arising from an AF tend to occur in patients aged approximately a decade older than those arising de novo [ 10 ]. Page views in The treatment of choice for AFS is radical surgical excision without primary neck dissection.

Ameloblastic fibrosarcoma AFS is a malignant odontogenic tumor characteristically composed of a benign epithelium and a malignant mesenchymal component [ 2 ]. Our patient presented an AFS in the posterior mandible.

Pathology Outlines – Malignant tumors: ameloblastic fibrosarcoma

The patient underwent a left hemimandibular resection and immediate fibular free flap reconstruction. Both neoplasms have a biphasic nature; however, AF has no malignant component, unlike AFS in which the mesenchymal component presents marked cellularity, nuclear pleomorphism, hyperchromatism, and a moderate to high number of mitotic figures.

After 2 years follow up, no evidence of recurrence was noted. Ameloblastic fibrosarcoma of the mandible: Maryam Khalili 1 and Pouyan Amini Shakib 2. According to these 62 published cases, the tumor is more common in males than females No evidence of regional lymphadenopathy or distant metastasis was found and a segmental resection of the maxilla along with wide excision of the surrounding amfloblastic tissues was performed.

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To the best of our knowledge, less than documented cases have been reported in the English language literature [ 6 ]. Author information Article notes Copyright and Firbo information Disclaimer. The surgeon decided to ask for a second opinion and sent the documents to our center for consultation.

As expected, the pain persisted and healing of the extraction site was not normal. Lectures on certain diseases of the jaws.

Radiographs show a radiolucent mass with ill-defined aeloblastic. Home About Us Advertise Amazon. Ameloblastic fibrosarcoma [title] mandible. Oral and Maxillofacial Pathology: Experimental and Therapeutic Medicine. Ameloblastic fibrosarcoma of the jaws – report of three cases.

Author information Article notes Copyright and License information Disclaimer. Clinical findings vary among reported cases but usually include pain and swelling. At the center of these islands is polyhedral cell reminiscent of stellate reticulum. Such location is the most frequent affected site reported in the literature.

Received Jan 11; Accepted Mar 2.

Low fibrk malignant neoplasm. Odontogenic tumors and tumor-like lesions constitute a rare group of heterogeneous diseases that range from nonneoplastic tissue proliferations to malignant tumors with metastatic potential.